Postdoctoral Fellow in AI/ML Applications for Vaccine Research & Development

Pfizer is a leading pharmaceutical company dedicated to delivering breakthroughs that transform patients' lives. They are seeking a Postdoctoral Fellow in AI/ML Applications for Vaccine Research & Development to develop advanced AI and machine learning models for predicting immunogenicity of pneumococcal conjugate vaccines, while collaborating with multidisciplinary teams and publishing scientific findings. Responsibilities - Develop advanced AI and machine learning models, including transformer architectures and graph neural networks, to represent molecular features and predict immunogenicity of pneumococcal conjugate vaccines using preclinical and clinical data - Apply transfer learning to translate predictive models from preclinical to clinical domains and utilize interpretation frameworks (such as SHAP) to identify key molecular motifs for rational vaccine design - Conduct meta-analyses of large-scale immunogenicity datasets to characterize quantitative relationships between vaccine physical parameters and immunogenicity outcomes - Harmonize and curate preclinical and clinical datasets to support robust statistical and machine learning analyses - Engage in active collaboration with multidisciplinary teams, encompassing experts in data science, preclinical analysis, and clinical vaccine research, to advance pneumococcal conjugate vaccines development - Publish impactful scientific findings while safeguarding confidential data, ensuring clear, transparent reporting of methods and results to facilitate reproducibility and recognition in peer-reviewed journals and conferences Skills - Ph.D. in Computational Biology, Bioinformatics, Computer Science, Immunology, or a related field - Less than 2 years of post-degree experience - Willingness to make a minimum 2-year commitment - Successful record of scientific accomplishments evidenced by scientific publications and/or presentations with at least one first-author publication in a peer-reviewed journal - Demonstrated expertise in machine learning and deep learning, with hands-on experience in developing and validating predictive models for biological or biomedical data - Proficiency in Python and relevant AI Machine Learning frameworks (e.g., PyTorch, TensorFlow, scikit-learn) - Experience with statistical modeling, including regression analysis and mixed-effects models - Solid understanding of immunology, especially vaccine immunogenicity and conjugate vaccine design - Strong data management and curation skills, including harmonization of heterogeneous biological datasets - Excellent scientific communication skills, with a track record of peer-reviewed publications or presentations - Ability to work across computational and wet‑lab teams, distill complex results for diverse stakeholders - Prior experience applying graph neural networks, transformer models, or cross-attention mechanisms to biological sequence or molecular structure data - Familiarity with glycan-focused modeling and representation, including encoding of polysaccharide and protein carrier features - Experience in translational research bridging preclinical and clinical datasets, especially in vaccine development - Knowledge of SHAP or similar model interpretation frameworks for feature attribution in complex models - Hands-on experience with ensemble modeling and transfer learning in biomedical contexts - Collaborative experience with experimental biologists and vaccine R&D teams - Familiarity with regulatory and translational aspects of vaccine development Benefits - Participation in Pfizer’s Global Performance Plan with a bonus target of 7.5% of the base salary - 401(k) plan with Pfizer Matching Contributions - Additional Pfizer Retirement Savings Contribution - Paid vacation - Holiday and personal days - Paid caregiver/parental and medical leave - Health benefits to include medical, prescription drug, dental and vision coverage Company Overview - Pfizer is a biopharmaceutical company that discovers, develops, and delivers medicines and vaccines. It was founded in 1849, and is headquartered in New York, New York, USA, with a workforce of 10001+ employees. Its website is http://www.pfizer.com.