← All Jobs
Apr 10, 2026

[Remote] Software Engineer - .NET Full Stack Developer

Apply Now
Note: The job is a remote job and is open to candidates in USA. Mayo Clinic Rochester is seeking a Software Engineer to design, develop, and maintain .NET-based back-end services for genomics and clinical applications. The role involves building and optimizing services for genomic workflows and collaborating with cross-functional teams to ensure high performance and reliability of the systems. Responsibilities - Designing and implementing services aligned to enterprise architecture, including cloud-ready APIs, data integration pipelines, and secure interoperability layers for genomic systems - Building and optimizing services that handle complex genomic workflows, large-scale clinical datasets, and high-throughput data processing - Ensuring that all services meet strict performance, reliability, and accuracy requirements, scale effectively as data volumes grow, and remain resilient within hybrid cloud ecosystems - Participating in Agile and DevOps practices using GitHub, Azure DevOps (ADO), Azure Pipelines, and CI/CD frameworks - Maintaining comprehensive technical documentation, contributing to code reviews, and participating in expert-level troubleshooting through log analysis, root cause evaluation, and data/system investigation Skills - Bachelor's degree in computer science/engineering or related field; Or an associate's degree in computer science/engineering or related field with an additional 2 years of experience as described below - Have working knowledge and experience of Software Engineering with a minimum of internships and a minimum of 1 year of experience, or 2 years of experience coding applications or services in a high-level language (C, C++, Golang, Java, C# etc.) - Demonstrated problem solving and time management skills - Possesses strong technical aptitude for designing and implementing software solutions - Experience with modern application development frameworks - Knowledge of professional software engineering practices & best practices for the full software development life cycle, including coding standards, code reviews, source control management, build processes, testing, and operations - Deep hands-on technical expertise, excellent verbal and written communication skills - Experience with Agile software development techniques - Experience developing applications in hybrid environments, including on-premises systems, Azure, and Google Cloud Platform (GCP) - Familiarity with building and integrating RESTful APIs, microservices, and web services using .NET technologies - Knowledge of DevOps pipelines and CI/CD using Azure DevOps, GitHub Actions, or Azure Pipelines - Utilization of AI coding tool such as GitHub CoPilot, Gemini, Claude - Experience with relational and NoSQL databases, analytics platforms, big-data processing, or enterprise data pipelines - Background in developing high-performance, scalable, and highly available distributed systems - Experience supporting or developing solutions in healthcare, clinical, Bioinformatics or genomics-focused applications is highly desirable - Ability to use a wide variety of open-source technologies and cloud-based services - Experience with Google and Azure cloud environments - Experience in databases, analytics, big data systems or business intelligence products - Experience with building high-performance, highly available and scalable distributed systems - Experience developing software for healthcare related industries Company Overview - Mayo Clinic Rochester is a hospital & health care company based out of 1025 Marsh St, Mankato, MN, United States. It was founded in undefined, and is headquartered in Mankato, MN, US, with a workforce of 201-500 employees. Its website is http://www.mayoclinichealthsystem.org.